1746-01-6 Dibenzo[b,e][1,4]dioxin,2,3,7,8-tetrachloro-

Name: Dibenzo[b,e][1,4]dioxin,2,3,7,8-tetrachloro-
Synonyms: Dibenzo-p-dioxin,2,3,7,8-tetrachloro- (6CI,7CI,8CI);2,3,7,8-TCDD;2,3,7,8-Tetrachloro-p-dioxin;2,3,7,8-Tetrachlorodibenzo-1,4-dioxin;2,3,7,8-Tetrachlorodibenzo-p-dioxin;2,3,7,8-Tetrachlorodibenzo[b,e][1,4]dioxin;2,3,7,8-Tetrachlorodibenzodioxin;D48;Dioxin;Dioxin (herbicide contaminant);PCDD 48;TCDBD;TCDD;Tetrachlorodibenzo-p-dioxin;Tetrachlorodibenzodioxin;
CAS Number:1746-01-6
Molecular Formula:C12H4 Cl4 O2
Molecular Weight:321.96
EINECS:
Density:1.643g/cm³
Boiling Point:500(dec)
Flash Point:164.2°C
Safety Description:Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. One of the most toxic synthetic chemicals. A deadly experimental poison by ingestion, skin contact, and intraperitoneal routes. Human systemic effects by skin contact: allergic dermatitis. Experimental reproductive effects. Human mutation data reported. An eye irritant.

TCDD is the most toxic member of the 75 dioxins. It causes death in rats by hepatic cell necrosis. Death can follow a lethal dose by weeks. Acute and subacute exposure result in wasting, hepatic necrosis, thymic atrophy, hemorrhage, lymphoid depletion, chloracne. A by-product of the manufacture of polychlorinated phenols. It is found at low levels in 2,4,5-T, 2,4,5-trichlorophenol, and hexachlorophene. It is also formed during various combustion processes. Incineration of chemical wastes, including chlorophenols, chlorinated benzenes, and biphenyl ethers, may result in the presence of TCDD in flue gases, fly ash, and soot particles. It is immobile in contaminated soil and may be retained for years. TCDD has the potential for bio-accumulation in animals. An accident in Seveso, Italy, and inadvertent soil contamination in Missouri have resulted in abandonment of the contaminated areas. When heated to decomposition it emits toxic fumes of Cl⁻.
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